BENZENE EXPOSURE ANALYSIS IN INFORMAL SHOE INDUSTRY WORKERS IN SUKAJAYA VILLAGE, WEST JAVA VIA LEUKOCYTE COUNT AND S-PHENYLMERCAPTURIC ACID MEASUREMENT IN URINE

Lora Agustina, Ririn Arminsih Wulandari

Abstract


Background: Benzene is a hematotoxic and carcinogenic compound contained in the glue used in the shoe industry. This compound has been suspected of causing decreased leukocyte counts, which is one of the blood cell production disorders. Benzene exposure can be determined by measuring the concentration of S-phenylmercapturic acid (S-PMA) in urine.

Objective: This study was conducted to determine the association between S-PMA urine concentration and the leukocyte count of shoe industry workers.

Methods: The study design was cross sectional and the data were collected by conducting interviews, analyzing urine samples for S-PMA concentrations, and conducting blood examinations. Chi square and multiple logistic regression were used for the analysis.

Results: The results showed there were no concentrations of S-PMA in urine that exceeded the Biological Exposure Index (BEI) value (≤25 μg/g creatinine). Higher S-PMA concentrations in this study show a higher risk of decreased leukocyte counts. When controlling for age, duration of work, history of infection, Body Mass Index (BMI), smoking, occupation, and exercise, workers with high S-PMA urine concentration were found to be at higher risk of a decreased leukocyte count.

Conclusion: Although S-PMA urine concentrations were still below BEI values, workers with higher S-PMA urine concentration were more at risk of leukocyte counts of < 5.0 x 103/μL. The decrease in the minimum BEI S-PMA limit value was lower than the current standard may need to be considered.


Keywords


benzene; S-phenylmercapturic acid; leukocyte; shoe workers

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References


Al Jothery, A. H. T., & Al-hassnwi, T. (2017). Changes in the hematological profile among workers at patrol stations in Babil Province/Iraq. Mesopotemia Environmental Journal. 3(4), 25-32.

Arnold, S. M., Angerer, J., Boogaard, P. J., Hughes, M. F., O’Lone, R. B., Robison, S. H., & Robert Schnatter, A. (2013). The use of biomonitoring data in exposure and human health risk assessment: benzene case study. Critical Reviews in Toxicology, 43(2), 119-153.

Barbieri, A., Violante, F. S., Sabatini, L., Graziosi, F., & Mattioli, S. (2008). Urinary biomarkers and low-level environmental benzene concentration: assessing occupational and general exposure. Chemosphere, 74(1), 64-69.

Dharma, R., Immanuel, S., & Wirawan, R. (1983). Penilaian hasil pemeriksaan hematologi rutin. Cermin Dunia Kedokteran, 30, 28-31.

Dosemeci, M., Yin, S., Linet, M., Wacholder, S., Rothman, N., Li, G., . . . Dai, T. (1996). Indirect validation of benzene exposure assessment by association with benzene poisoning. Environmental Health Perspectives, 104(suppl 6), 1343-1347.

Ekasari, R., & Arminsih, R. (2019). Benzene exposure analysis via the biomarker s-phenylmercapturic acid and hemoglobin levels of shoemakers in Sukajaya Village, West Java Province, Indonesia. Journal of International Dental and Medical Research, 12(2), 828-832.

Farmer, P. B., Kaur, B., Roach, J., Levy, L., Consonni, D., Bertazzi, P. A., . . . Bonzini, M. (2005). The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene. Chemico-Biological Interactions, 153, 97-102.

Fustinoni, S., Buratti, M., Campo, L., Colombi, A., Consonni, D., Pesatori, A. C., . . . Valerio, F. (2005). Urinary t, t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure. Chemico-Biological Interactions, 153, 253-256.

Gordon, S. M., Wallace, L. A., Brinkman, M. C., Callahan, P. J., & Kenny, D. V. (2002). Volatile organic compounds as breath biomarkers for active and passive smoking. Environmental Health Perspectives, 110(7), 689-698.

Haen, M. T., & Oginawati, K. (2011). Hubungan pajanan senyawa benzena, toluena dan xylen dengan sistem hematologi pekerja di kawasan industri sepatu. Fakultas Teknik Sipil dan Lingkungan. ITB.

Lan, Q., Zhang, L., Li, G., Vermeulen, R., Weinberg, R. S., Dosemeci, M., . . . Wu, Y. (2004). Hematotoxicity in workers exposed to low levels of benzene. Science, 306(5702), 1774-1776.

McGrath, C. R., Hitchcock, D. C., & van Assendelft, O. W. (1982). Total white blood cell counts for persons ages 1-74 years with differential leukocyte counts for adults ages 25-74 years: United States, 1971-75. Vital and Health Statistics. Series 11, Data from the National Health Survey(220), 1.

Mehta, A., & Hoffbrand, V. (2006). At a glance hematologi. Edisi kedua. Jakarta: Erlangga.

Nieman, D. C. (2000). Exercise effects on systemic immunity. Immunology and Cell Biology, 78(5), 496-501.

Nugraha, D. A. (2017). Perbaikan lingkungan kerja di sektor alas kaki informal Cibaduyut dengan Participatory Ergonomics: studi kasus di tiga bengkel.

Perbellini, L., Veronese, N., & Princivalle, A. (2002). Mercapturic acids in the biological monitoring of occupational exposure to chemicals. Journal of Chromatography B, 781(1-2), 269-290.

Rajamurugan, R., Suyavaran, A., Selvaganabathy, N., Ramamurthy, C., Reddy, G. P., Sujatha, V., & Thirunavukkarasu, C. (2012). Brassica nigra plays a remedy role in hepatic and renal damage. Pharmaceutical Biology, 50(12), 1488-1497.

Santos, M. d. A., Tavora, B. E., Koide, S., & Caldas, E. D. (2013). Human risk assessment of benzene after a gasoline station fuel leak. Revista de saude publica, 47, 335-344.

Swaen, G. M., van Amelsvoort, L., Twisk, J. J., Verstraeten, E., Slootweg, R., Collins, J. J., & Burns, C. J. (2010). Low level occupational benzene exposure and hematological parameters. Chemico-Biological Interactions, 184(1-2), 94-100.

Tsai, S. P., Fox, E. E., Ransdell, J. D., Wendt, J. K., Waddell, L. C., & Donnelly, R. P. (2004). A hematology surveillance study of petrochemical workers exposed to benzene. Regulatory Toxicology and Pharmacology, 40(1), 67-73.

Wilbur, S., Wohlers, D., Paikoff, S., Keith, L., & Faroon, O. (2008). ATSDR evaluation of health effects of benzene and relevance to public health. Toxicology and Industrial Health, 24(5-6), 263-398.




DOI: https://doi.org/10.36685/phi.v5i4.300

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