Supplementary Files
Keywords
neuropathy diabetic
pain
How to Cite
Abstract
Background: Pain is quite often felt in approximately 30 to 50% of people with diabetic neuropathy. As a result, the quality of life is low, indicated by the high morbidity and mortality rates. The availability of symptomatic pharmacological agents has the potential to have side effects and adverse effects in the elderly and in addition to the high risk of addiction. Complementary therapy and alternative medicine in chronic pain are clinically safe, cost-effective, and affordable. However, scientific evidence of its effectiveness is limited.
Objective: This systematic review aims to evaluate the intervention modalities and the effectiveness of complementary and alternative medicine therapy in diabetic neuropathy pain.
Methods: The searched literature databases included PubMed, ProQuest, ScienceDirect, EBSCO host, DOAJ, Clinical Key for Nursing, and Cochrane. The criteria for the article, among others, focus on complementary therapy and alternative medicine in diabetic neuropathy pain, publications in the last five years, full text, and in English.
Results: Fifteen articles were identified in reporting the effectiveness of complementary therapy and alternative medicine in reducing diabetic neuropathy pain, including mindfulness-based stress reduction, mindfulness meditation, relaxation, whole-body vibration, Abzan, aerobic resistance training, nano curcumin, Citrullus colocynthis, dietary, acupuncture, laser, and reflexology.
Conclusion: Most scientific evidence reports the effectiveness of complementary and alternative medicine therapies in reducing pain in diabetic neuropathy, thus strengthening its application as an adjunct to conventional medicine is needed.
References
American Diabetes Association. (2020). Standards of medical care in diabetes”2020. Diabetes Care, 43(Supplement 1), 1-224.
Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., Khamoshian, K., & Sotoudeh, G. (2019). Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled clinical trial. Complementary Therapies in Medicine, 43, 253-260. https://doi.org/10. 1016/j.ctim.2019.02.014
Aslam, A., Singh, J., & Rajbhandari, S. (2014). Pathogenesis of painful diabetic neuropathy. Pain Research and Treatment, 2014. http://dx.doi.org/10. 1155/2014/412041
Barnard, N. D., Scialli, A. R., Turner-McGrievy, G., Lanou, A. J., & Glass, J. (2005). The effects of a low-fat, plant-based dietary intervention on body weight, metabolism, and insulin sensitivity. The American Journal of Medicine, 118(9), 991-997. https://doi.org/10.1016/ j.amjmed.2005.03.039
Bašić-Kes, V., Zavoreo, I., Rotim, K., Bornstein, N., Rundek, T., & Demarin, V. (2011). Recommendations for diabetic polyneuropathy treatment. Acta Clinica Croatica, 50(2), 289-302.
Bauer, B. A., Tilburt, J. C., Sood, A., Li, G.-x., & Wang, S.-h. (2016). Complementary and alternative medicine therapies for chronic pain. Chinese Journal of Integrative Medicine, 22(6), 403-411. https://doi.org/ 10.1007/s11655-016-2258-y
Baute, V., Zelnik, D., Curtis, J., & Sadeghifar, F. (2019). Complementary and alternative medicine for painful peripheral neuropathy. Current Treatment Options in Neurology, 21(9), 1-15. https://doi.org/10.1007/s11940 -019-0584-z
Behzadmehr, R., Dastyar, N., Moghadam, M. P., Abavisani, M., & Moradi, M. (2020). Effect of complementary and alternative medicine interventions on cancer related pain among breast cancer patients: A systematic review. Complementary Therapies in Medicine, 49, 102318. https://doi.org/10.1016/j.ctim. 2020.102318
Bunner, A., Wells, C., Gonzales, J., Agarwal, U., Bayat, E., & Barnard, N. D. (2015). A dietary intervention for chronic diabetic neuropathy pain: A randomized controlled pilot study. Nutrition & Diabetes, 5(5), e158-e158. https://doi.org/10.1038/nutd.2015.8
í‡akici, N., Fakkel, T., Van Neck, J., Verhagen, A., & Coert, J. (2016). Systematic review of treatments for diabetic peripheral neuropathy. Diabetic medicine, 33(11), 1466-1476. https://doi.org/10.1111/dme.13083
CASP, U. (2013). Critical appraisal skills programme. Randomised Controlled Trail Checklist Zugriff am, 18, 2015. https://doi.org/10.4103/0976-500X.107697
Chao, M. T., Schillinger, D., Nguyen, U., Santana, T., Liu, R., Gregorich, S., & Hecht, F. M. (2019). A randomized clinical trial of group acupuncture for painful diabetic neuropathy among diverse safety net patients. Pain Medicine, 20(11), 2292-2302. https://doi.org/10.1093/ pm/pnz117
Chatterjee, P., Srivastava, A. K., Kumar, D. A., Chakrawarty, A., Khan, M. A., Ambashtha, A. K., . . . Dey, A. B. (2019). Effect of deep tissue laser therapy treatment on peripheral neuropathic pain in older adults with type 2 diabetes: A pilot randomized clinical trial. BMC Geriatrics, 19(1), 1-10. https://doi.org/10.1186/ s12877-019-1237-5
Cherry, B., & Jacob, S. R. (2016). Contemporary nursing: Issues, trends, & management (8th ed.). Philadelphia: Elsevier Health Sciences.
Eriksen, M. B., & Frandsen, T. F. (2018). The impact of patient, intervention, comparison, outcome (PICO) as a search strategy tool on literature search quality: A systematic review. Journal of the Medical Library Association: JMLA, 106(4), 420. https://doi.org/10. 5195/jmla.2018.345
Forouzanfar, F., & Hosseinzadeh, H. (2018). Medicinal herbs in the treatment of neuropathic pain: A review. Iranian Journal of Basic Medical Sciences, 21(4), 347. https://doi.org/10.22038/IJBMS.2018.24026.6021
Hassed, C. (2013). Mind-body therapies: Use in chronic pain management. Australian Family Physician, 42(3), 112-117.
Heydari, M., Homayouni, K., Hashempur, M. H., & Shams, M. (2016). Topical C itrullus colocynthis (bitter apple) extract oil in painful diabetic neuropathy: A double"blind randomized placebo"controlled clinical trial. Journal of diabetes, 8(2), 246-252. https://doi.org/10.1111/1753-0407.12287
Higgins, J. P., Sterne, J. A., Savovic, J., Page, M. J., Hróbjartsson, A., Boutron, I., . . . Eldridge, S. (2016). A revised tool for assessing risk of bias in randomized trials. Cochrane Database of Systematic Reviews, 10(Suppl 1), 29-31.
Higgins, J. P. T., Altman, D. G., Gí¸tzsche, P. C., Jüni, P., Moher, D., Oxman, A. D., . . . Sterne, J. A. C. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, d5928. https://doi.org/10.1136/bmj.d5928
Hussain, N., & Said, A. S. (2019). Mindfulness-based meditation versus progressive relaxation meditation: Impact on chronic pain in older female patients with diabetic neuropathy. Journal of Evidence-based Integrative Medicine, 24, 2515690X19876599. https://doi.org/10.1177/2515690X19876599
Ibrahim, M. M., & Rizk, S. M. A. (2018). The efficacy of foot reflexology on the reduction of peripheral diabetic neuropathic pain. IOSR Journal of Nursing and Health Science (IOSR-JNHS), 7(5), 44-55.
Iqbal, Z., Azmi, S., Yadav, R., Ferdousi, M., Kumar, M., Cuthbertson, D. J., . . . Alam, U. (2018). Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy. Clinical Therapeutics, 40(6), 828-849. https://doi.org/10.1016/j.clinthera.2018.04.001
Izgu, N., Gok Metin, Z., Karadas, C., Ozdemir, L., Metinarikan, N., & Corapcıoglu, D. (2020). Progressive muscle relaxation and mindfulness meditation on neuropathic pain, fatigue, and quality of life in patients with type 2 diabetes: A randomized clinical trial. Journal of Nursing Scholarship, 52(5), 476-487. https://doi.org/ 10.1111/jnu.12580
Jamal, A., Ahmad, I., Ahamed, N., Azharuddin, M., Alam, F., & Hussain, M. E. (2019). Whole body vibration showed beneficial effect on pain, balance measures and quality of life in painful diabetic peripheral neuropathy: A randomized controlled trial. Journal of Diabetes & Metabolic Disorders, 1-9. https://doi.org/ 10.1007/s40200-019-00476-1
Kabisch, M., Ruckes, C., Seibert-Grafe, M., & Blettner, M. (2011). Randomized controlled trials: part 17 of a series on evaluation of scientific publications. Deutsches í„rzteblatt International, 108(39), 663. https://doi.org/10.3238/arztebl.2011.0663
Kemppainen, L. M., Kemppainen, T. T., Reippainen, J. A., Salmenniemi, S. T., & Vuolanto, P. H. (2018). Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants. Scandinavian Journal of Public Health, 46(4), 448-455. https://doi.org/10.1177/1403494817733869
Kessler, N. J., Lockard, M. M., & Fischer, J. (2020). Whole body vibration improves symptoms of diabetic peripheral neuropathy. Journal of Bodywork and Movement Therapies, 24(2), 1-3. https://doi.org/ 10.1016/j.jbmt.2020.01.004
Lee, F. H., & Raja, S. N. (2011). Complementary and alternative medicine in chronic pain. Pain, 152(1), 28-30. https://doi.org/10.1016/j.pain.2010.09.023
Lewis, S. L., Dirksen, S. R., Heitkemper, M. M., & Bucher, L. (2014). Medical-surgical nursing: Assessment and management of clinical problems (9th ed.). St. Louis Missouri: Elsevier Mosby.
Mehta, P., Dhapte, V., Kadam, S., & Dhapte, V. (2017). Contemporary acupressure therapy: Adroit cure for painless recovery of therapeutic ailments. Journal of traditional and complementary medicine, 7(2), 251-263. https://doi.org/10.1016/j.jtcme.2016.06.004
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & Group, P. (2014). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. Revista Española de Nutrición Humana y Dietética, 18(3), 172-181.
Nash, J., Armour, M., & Penkala, S. (2019). Acupuncture for the treatment of lower limb diabetic peripheral neuropathy: A systematic review. Acupuncture in Medicine, 37(1), 3-15. https://doi.org/10.1136/ acupmed-2018-011666
Nathan, H. J., Poulin, P., Wozny, D., Taljaard, M., Smyth, C., Gilron, I., . . . Shergill, Y. (2017). Randomized trial of the effect of mindfulness-based stress reduction on pain-related disability, pain intensity, health-related quality of life, and A1C in patients with painful diabetic peripheral neuropathy. Clinical Diabetes, 35(5), 294-304. https://doi.org/10.2337/cd17-0077
Parsa, T. A., Hosseini, S. R. A., Bije, N., & Nia, M. R. H. (2018). The study of the effect of a 16-week program of resistance-aerobic training on BDNF, Hba1c, pain, and michigan neuropathy score among type 2 diabetic patients with peripheral neuropathy. Journal of Diabetes & Metabolism, 9(11), 1-12.
Peltier, A., Goutman, S. A., & Callaghan, B. C. (2014). Painful diabetic neuropathy. BMJ, 348. https://doi.org/ 10.1136/bmj.g1799
Peltzer, K., & Pengpid, S. (2015). Utilization and practice of traditional/complementary/alternative medicine (T/CAM) in Southeast Asian nations (ASEAN) member states. Studies on Ethno-Medicine, 9(2), 209-218. https://doi.org/10.1080/09735070.2015.11905437
Polit, D. F., & Beck, C. T. (2009). Essentials of nursing research: Appraising evidence for nursing practice. Philadelphia: Lippincott Williams & Wilkins.
Shanb, A. A., Youssef, E. F., Al Baker, W. I., Al-Khamis, F. A., Hassan, A., & Jatoi, N.-A. (2020). The efficacy of adding electromagnetic therapy or laser therapy to medications in patients with diabetic peripheral neuropathy. Journal of Lasers in Medical Sciences, 11(1), 20. https://doi.org/10.15171/jlms.2020.05
Spallone, V., Lacerenza, M., Rossi, A., Sicuteri, R., & Marchettini, P. (2012). Painful diabetic polyneuropathy: approach to diagnosis and management. The Clinical Journal of Pain, 28(8), 726-743. https://doi.org/10. 1097/AJP.0b013e318243075c
Steel, A., McIntyre, E., Harnett, J., Foley, H., Adams, J., Sibbritt, D., . . . Frawley, J. (2018). Complementary medicine use in the Australian population: Results of a nationally-representative cross-sectional survey. Scientific Reports, 8(1), 1-7. https://doi.org/10. 1038/s41598-018-35508-y
Tesfaye, S., Vileikyte, L., Rayman, G., Sindrup, S. H., Perkins, B., Baconja, M., . . . Neuropathy, T. E. P. o. D. (2011). Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management. Diabetes/Metabolism Research and Reviews, 27(7), 629-638. https://doi.org/ 10.1002/dmrr.1225
Vakilinia, S. R., Vaghasloo, M. A., Aliasl, F., Mohammadbeigi, A., Bitarafan, B., Etripoor, G., & Asghari, M. (2020). Evaluation of the efficacy of warm salt water foot-bath on patients with painful diabetic peripheral neuropathy: A randomized clinical trial. Complementary Therapies in Medicine, 49, 102325. https://doi.org/10.1016/j.ctim.2020.102325
Win, M. M. T. M., Fukai, K., Nyunt, H. H., & Linn, K. Z. (2020). Hand and foot exercises for diabetic peripheral neuropathy: A randomized controlled trial. Nursing & Health Sciences, 22(2), 416-426. https://doi.org/ 10.1111/nhs.12676
Zakin, E., Abrams, R., & Simpson, D. M. (2019). Diabetic neuropathy. Paper presented at the Seminars in Neurology.
Authors who publish with Public Health of Indonesia agree to the following terms:
- Authors retain copyright licensed under a Creative Commons Attribution-NonCommercial CC BY-NC 4.0, which allows others to remix, tweak, and build upon the authors' work non-commercially, and although the others' new works must also acknowledge the authors and be non-commercial, they don't have to license their derivative works on the same terms.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). Authors can archive pre-print and post-print or publisher's version/PDF.